The patient’s acute GBS in the setting of recent severe COVID-19 infection strongly suggests association between the two entities, as supported by a growing body of case literature. Blood cultures, serum polymerase chain reaction testing, and clinical symptoms were not suggestive of other common pathogens causing his GBS. Analysis of his cerebrospinal fluid showed a cytoalbuminologic dissociation, and electromyography/nerve conduction study showed slowed nerve conduction velocity. Three days later, he developed acute, symmetric limb quadriparesis and respiratory muscle failure requiring reintubation. On hospital day 32, the patient was extubated. He was subsequently intubated and treated with dexamethasone and remdesivir with improvement. A 69-year-old male was admitted to the ICU for acute hypoxemic respiratory failure due to COVID-19 pneumonia. We describe the diagnostic process behind diagnosing GBS in an elderly male who developed acute-onset quadriparesis and respiratory muscle failure associated with severe COVID-19 pneumonia in a military ICU. Guillain–Barre syndrome (GBS) is a rarely diagnosed but severe disease associated with COVID-19 infection. Most COVID-19 infections are associated with lower respiratory abnormalities but it has been increasingly associated with extra-pulmonary manifestations. Coronavirus disease 2019 (COVID-19) is a significant cause for intensive care unit (ICU) admission worldwide.

Guillain barre csf findings